Reduced tyrosine kinase inhibitor dose is predicted to be as effective as standard dose in chronic myeloid leukemia: a simulation study based on phase III trial data

Continuing tyrosine kinase inhibitor (TKI)-mediated targeting of the BCR-ABL1 oncoprotein is the standard therapy for chronic myeloid leukemia (CML) and allows for a sustained disease control in the majority of patients.While therapy cessation for patients appeared as a safe option for about half of those patients with optimal response, no systemat

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Life Cycle Assessment of Cold Spray Additive Manufacturing and Conventional Machining of Aluminum Alloy Flange

Cold spray additive manufacturing (CSAM) is generally used to repair worn components and build complex on-demand parts by depositing metal powder layer-wise using compressed air.Previous studies on CSAM were focused on printing parameters, materials properties, and printed part mechanical performance.However, the energy consumption and environmenta

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